Real time Raman Analysis for Continuous Flow: Rapid In-Line Analysis of Low Levels of an Analyte

Flow chemistry is used in many aspects of industrial processing including (but not limited to) continuous reaction chemistry, preparation and quantification of feedstocks, and product purification processes. Analytical monitors for flow chemistry processes can provide precise, accurate, and timely measurements to ensure that products or excipients are properly quantified and are being produced with maximum efficiency. However, current spectroscopic tools are limited to bulk analysis and are a bottleneck in many applications. Tornado Spectral Systems HyperFlux™ PRO Plus puts Raman into the forefront of monitoring and controlling these highly dynamic processes. This application note demonstrates the benefit of HTVS™ for in-line method development and real-time predictions of a low-level analyte in a continuous process.